Title

Assessment Of Molecular Interactions Through Magnetic Relaxation

Keywords

dissociation constants; magnetic nanoparticles; membrane receptors; protein-ligand interactions; protein-protein interactions

Abstract

Just relax: The dissociation constants (KD) of various molecular interactions can be determined using a novel competition assay with binding magnetic relaxation nanosensors. In this assay, changes in the magnetic relaxation (MR) of an aqueous suspension of the nanosensors facilitate the fast determination of KD values by using nanomolar protein concentrations (see picture). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Publication Date

7-2-2012

Publication Title

Angewandte Chemie - International Edition

Volume

51

Issue

27

Number of Pages

6728-6732

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/anie.201202077

Socpus ID

84863228084 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84863228084

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