Title

Cellular Therapy For Ovarian Cancer: Experimental And Clinical Perspectives

Keywords

Cellular therapy; Clinical outcomes; Experimental models; Immunosuppression; Ovarian cancer; Targeted therapy

Abstract

Ovarian cancer is the leading cause of death among gynecologic malignancies and the 5th leading cause of cancer deaths for women in the United States. Two-thirds of patients present with advanced-stage disease (Stage III and IV) and the majority will suffer recurrence of disease, require ongoing treatment, and eventually succumb to chemotherapy-resistant disease. To potentially circumvent chemo-resistance in recurrent ovarian cancer, immunotherapy is being explored as a novel treatment option. Our laboratory findings demonstrate that immune effector cells from healthy donors elicit a significant cytotoxic response in the presence of IL-2 and IFN alpha- 2b against ovarian cancer in vitro; however, peripheral blood mononuclear cells (PBMC) isolated from ovarian cancer patients fail to elicit a similar response. A major obstacle to immunotherapy is the immunosuppressive environment supported by tumors, which limits the immune system's ability to fight the tumor. Myeloid-derived suppressor cells are an immature population of myeloid cells, which have recently been implicated to play a major role in immunosuppression and tumor evasion. In addition to novel immunotherapies, new diagnostic and prognostic markers are being identified through applying molecular tools/approaches in clinical and pathological analyses of this malignancy, which will provide additional therapeutic targets. To test these experimental therapeutic options, pre-clinical murine models of ovarian cancer are being developed. Ultimately, treatment of ovarian cancer will benefit from the careful alignment of appropriate target, drug, patient, and trial design. This article provides an objective overview of cellular therapy (the use of immune cells to elicit an anti-tumor response) for ovarian cancer highlighting both experimental and clinical perspectives. © 2012 Bentham Science Publishers.

Publication Date

8-1-2012

Publication Title

Current Medicinal Chemistry

Volume

19

Issue

22

Number of Pages

3787-3793

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.2174/092986712801661158

Socpus ID

84865275876 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84865275876

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