Title

On-Chip Radiation Biodosimetry With Three-Dimensional Microtissues

Abstract

This paper reports an image-based, on-chip microtissue radiation biodosimeter that can simultaneously monitor radiation responses of multiple mammalian cell types. The microtissue chip is fabricated by molding molten agarose gel onto microfabricated patterns to form microwells, and seeding a variety of cell suspensions into different microwells inside the agarose gel. The camera of a mobile phone is used to collect images of an array of microtissues, and the color changes of microtissues upon X-ray irradiation allow accurate determination of cell death, which is related to radiation dose. The images can be transferred wirelessly, allowing the biodosimeter to be used for convenient and field deployable monitoring of radiation exposure. © The Royal Society of Chemistry 2012.

Publication Date

8-7-2012

Publication Title

Analyst

Volume

137

Issue

15

Number of Pages

3441-3444

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/c2an35046g

Socpus ID

84863654399 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84863654399

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