Title

Tuning Multiple Motor Travel Via Single Motor Velocity

Keywords

Cargo travel; Kinesin; Multiple-motor transport; Transport regulation; Velocity

Abstract

Microtubule-based molecular motors often work in small groups to transport cargos in cells. A key question in understanding transport (and its regulation in vivo) is to identify the sensitivity of multiple-motor-based motion to various single molecule properties. Whereas both single-motor travel distance and microtubule binding rate have been demonstrated to contribute to cargo travel, the role of single-motor velocity is yet to be explored. Here, we recast a previous theoretical study, and make explicit a potential contribution of velocity to cargo travel. We test this possibility experimentally, and demonstrate a strong negative correlation between single-motor velocity and cargo travel for transport driven by two motors. Our study thus discovers a previously unappreciated role of single-motor velocity in regulating multiple-motor transport. © 2012 John Wiley & Sons A/S.

Publication Date

9-1-2012

Publication Title

Traffic

Volume

13

Issue

9

Number of Pages

1198-1205

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1111/j.1600-0854.2012.01385.x

Socpus ID

84865175205 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84865175205

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