Title

Biochemical Basis And Clinical Consequences Of Glucolipotoxicity: A Primer

Keywords

Glucolipotoxicity; Insulin resistance; Pancreatic β-cell dysfunction

Abstract

Both glucose and fatty acids may have good/adaptive or toxic/maladaptive actions on the pancreatic beta cell, depending on their concentrations. Hyperglycemia, via metabolic intermediates, may result in multiple cellular effects that are toxic to the pancreatic beta cell and indeed other tissues. While free fatty acids may affect cellular processes beyond lipid metabolism by interacting with transcription factors, triglyceride rich lipoproteins are endothelial cell-toxic and facilitate atherogenesis. The paradigm of "glucolipotoxicity" espouses that increased glucose and fatty acid levels act synergistically in causing toxicity to pancreatic islets and other organs, a process that eventually leads to the multiple defects seen in the metabolic syndrome and diabetes mellitus. © 2012 Elsevier Inc.

Publication Date

10-1-2012

Publication Title

Heart Failure Clinics

Volume

8

Issue

4

Number of Pages

501-511

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.hfc.2012.06.011

Socpus ID

84866606916 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84866606916

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