Title

The Role Of University Of Central Florida In Regional Economic Development

Keywords

Antioxidant; Gene expression; Longevity; Nanoceria; Retinal degeneration; Tubby mouse

Abstract

We previously reported that nanoceria can slow retinal degeneration in the tubby mouse for two weeks by multiple systemic injections. However, the long-term protection of retinal structure and function by directly deliver of nanoceria to the eye had not been explored. In this study, 172 ng of nanoceria in 1 μl saline (1 m. m) were intravitreally injected into tubby P7 pups and assays were performed at P28, P49, P80 and P120. The expression of antioxidant associated genes and photoreceptor-specific genes was significantly up regulated, the mislocalization of rod and cone opsins was decreased, and retinal structure and function were protected. These findings demonstrate that nanoceria can function as catalytic antioxidants in vivo and may be broad spectrum therapeutic agents for multiple types of ocular diseases. © 2012 Elsevier Ltd.

Publication Date

1-1-2012

Publication Title

Technology Transfer in a Global Economy

Issue

34

Number of Pages

117-120

Document Type

Article; Book Chapter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/978-1-4614-6102-9_7

Socpus ID

85028640328 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85028640328

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