Title

Influence Of Relaxations On Acoustic Solitons

Keywords

adipogenesis; angiogenesis; cardiovascular disease; osteoclastogenesis; type 2 diabetes

Abstract

Numerous inflammatory cytokines have been implicated in the pathogenesis of cardiovascular diseases. Monocyte chemoattractant protein (MCP)-1/CCL2 is expressed by mainly inflammatory cells and stromal cells such as endothelial cells, and its expression is upregulated after proinflammatory stimuli and tissue injury. MCP-1 can function as a traditional chemotactic cytokine and also regulates gene transcription. The recently discovered novel zinc-finger protein, called MCPIP (MCP-1-induced protein), initiates a series of signaling events that causes oxidative and endoplasmic reticulum (ER) stress, leading to autophagy that can result in cell death or differentiation, depending on the cellular context. After a brief review of the basic processes involved in inflammation, ER stress, and autophagy, the recently elucidated role of MCP-1 and MCPIP in inflammatory diseases is reviewed. MCPIP was found to be able to control inflammatory response by inhibition of nuclear factor-κB activation through its deubiquitinase activity or by degradation of mRNA encoding a set of inflammatory cytokines through its RNase activity. The potential inclusion of such a novel deubiquitinase in the emerging anti-inflammatory strategies for the treatment of inflammation-related diseases such as cardiovascular diseases and type 2 diabetes is briefly discussed. © 2011 American Heart Association, Inc.

Publication Date

1-9-2012

Publication Title

Physics Letters, Section A: General, Atomic and Solid State Physics

Volume

376

Issue

1

Number of Pages

432-437

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.physleta.2011.11.044

Socpus ID

84855186569 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84855186569

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