Title

A Negative Sequence Compensation Method Based On A Two-Phase Three-Wire Converter For A High-Speed Railway Traction Power Supply System

Keywords

Aurora A; LIMK1; Mitotic spindle; Phosphorylation

Abstract

Aurora kinase A (Aur-A), a mitotic kinase, regulates initiation of mitosis through centrosome separation and proper assembly of bipolar spindles. LIM kinase 1 (LIMK1), a modulator of actin and microtubule dynamics, is involved in the mitotic process through inactivating phosphorylation of cofilin. Phosphorylated LIMK1 is recruited to the centrosomes during early prophase, where it colocalizes with γ-tubulin. Here, we report a novel functional cooperativity between Aur-A and LIMK1 through mutual phosphorylation. LIMK1 is recruited to the centrosomes during early prophase and then to the spindle poles, where it colocalizes with Aur-A. Aur-A physically associates with LIMK1 and activates it through phosphorylation, which is important for its centrosomal and spindle pole localization. Aur-A also acts as a substrate of LIMK1, and the function of LIMK1 is important for its specific localization and regulation of spindle morphology. Taken together, the novel molecular interaction between these two kinases and their regulatory roles on one other's function may provide new insight on the role of Aur-A in manipulation of actin and microtubular structures during spindle formation. © 2012 Landes Bioscience.

Publication Date

1-16-2012

Publication Title

IEEE Transactions on Power Electronics

Volume

27

Issue

2

Number of Pages

706-717

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1109/TPEL.2011.2159273

Socpus ID

84862938681 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84862938681

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