Title

Training Responses And Adaptations Of The Endocrine System

Keywords

Immunochemistry; in vitro test; mesenchymal stem cell; neural cell; surface modification; three-dimensional

Abstract

Umbilical cord stem cells would be a favorable alternative to embryonic stem cells for therapeutic applications. In this study, human multipotent progenitor cells (MLPCs) from umbilical cord were differentiated into oligodendrocytes by being exposed to a range of microenvironmental chemical and physical cues. Chemical cues were represented by a novel defined differentiation medium containing the neurotransmitter norepinephrine (NE). Under traditional two-dimensional conditions, the MLPCs differentiated into oligodendrocyte precursors but did not progress further. However, in a three-dimensional environment, the MLPCs differentiated into committed oligodendrocytes that expressed myelin basic protein. The apparent method of interaction of NE in stimulating the differentiation process was shown to occur through the adenergic pathway, while all prior differentiation methods have used other routes. This novel method of obtaining functional human oligodendrocytes from MLPCs would eliminate many of the difficulties associated with their differentiation from embryonic stem cells. © 2011 American Chemical Society.

Publication Date

1-18-2012

Publication Title

Conditioning for Strength and Human Performance: Second Edition

Issue

1

Number of Pages

109-142

Document Type

Article; Book Chapter

Personal Identifier

scopus

Socpus ID

84970960069 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84970960069

This document is currently not available here.

Share

COinS