Title

Small Molecule Stat5-Sh2 Domain Inhibitors Exhibit Potent Antileukemia Activity

Keywords

Liquid crystal alignments; Phase-separated organosilane monolayers

Abstract

We investigate the alignment of 4'-pentyl-4-cynobiphenyl (5CB) liquid crystal on phase-separated two-component organosilane monolayers that consist of the protruding islands surrounded by a continuous phase. The molecular disordering at the protruding island edge locally perturbs the homeotropic alignment of the 5CB induced the phase-separated monolayers, leading to the formation of ring patterns. The edge effect on the 5CB alignment decreases with the decrease of the height difference between the protruding islands and the surrounding monolayer and increases with the decrease of the size of the protruding islands. © 2011 Elsevier B.V.

Publication Date

2-9-2012

Publication Title

Journal of Medicinal Chemistry

Volume

55

Number of Pages

1047-1055

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/jm200720n

Socpus ID

84856845674 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84856845674

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