Title

Unique Example Of Amyloid Aggregates Stabilized By Main Chain H-Bond Instead Of The Steric Zipper: Molecular Dynamics Study Of The Amyloidogenic Segment Of Amylin Wild-Type And Mutants

Keywords

Brodmann area 10; Cognition; Emotional intelligence; Neuropsychology; Prefrontal lesions

Abstract

Background: The frontopolar cortex has been proposed to mediate prospective memory functioning, multitasking, relational integration, processing of internal states, and self-referential evaluation. These theories are based primarily on functional activation studies. The few lesion models reported have not been restricted to the frontopolar cortex. Aim: We used neuropsychological tests and neuroimaging to study an otherwise healthy woman with an isolated hemorrhagic infarct in the frontopolar cortex. Methods: In addition to a standard stroke work-up, the patient had cognitive psychometric tests reflecting the theoretical frontal functions of initiation, monitoring, inhibition, and working memory, as well as a test for emotional intelligence. Results: The midline frontopolar intracerebral hemorrhage was isolated, free of other pathology, and almost solely within Brodmann area 10. The only psychometric abnormalities concerned awareness of, understanding, and expressing emotions. Conclusions: This report may be the first of an isolated bilateral lesion of the frontopolar cortex, Brodmann area 10, with uniformly normal frontal lobe tests except for 2 abnormal findings of emotional intelligence. This lesion study supports the proposal that the medial frontopolar cortex is necessary for emotional processing of internal states. Copyright © 2012 by Lippincott Williams & Wilkins.

Publication Date

3-1-2012

Publication Title

Journal of Molecular Modeling

Volume

18

Issue

1

Number of Pages

891-903

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s00894-011-1030-7

Socpus ID

84861332104 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84861332104

This document is currently not available here.

Share

COinS