Title

Dense And Dynamic 3D Selection For Game-Based Virtual Environments

Abstract

Monitoring of microenvironmental parameters is critical in healthcare and disease management. Harnessing the antioxidant activity of nanoceria and the imaging capabilities of iron oxide nanoparticles in a device setup, we were able to image changes in the device's aqueous milieu. The device was able to convey and process changes in the microenvironment's pH and reactive oxygen species' concentration, distinguishing physiological from abnormal levels. As a result under physiological and transient inflammatory conditions, the device's fluorescence and magnetic resonance signals, emanating from multimodal iron oxide nanoparticles, were similar. However, under chronic inflammatory conditions that are usually associated with high local concentrations of reactive oxygen species and pH decrease, the device's output was considerably different. Specifically, the device's fluorescence emission significantly decreased, while the magnetic resonance signal T2 increased. Further studies identified that the changes in the device's output are attributed to inactivation of the sensing component's nanoceria that prevents it from successfully scavenging the generated free radicals. Interestingly, the buildup of free radical excess led to polymerization of the iron oxide nanoparticle's coating, with concomitant formation of micron size aggregates. Our studies indicate that a nanoceria-based device can be utilized for the monitoring of pro-inflammatory biomarkers, having important applications in the management of numerous ailments while eliminating nanoparticle toxicity issues. © The Royal Society of Chemistry 2012.

Publication Date

3-22-2012

Publication Title

IEEE Transactions on Visualization and Computer Graphics

Volume

18

Issue

6

Number of Pages

634-642

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1109/TVCG.2012.40

Socpus ID

84858388169 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84858388169

This document is currently not available here.

Share

COinS