Title

Antibody-Conjugated Pegylated Cerium Oxide Nanoparticles For Specific Targeting Of Aβ Aggregates Modulate Neuronal Survival Pathways

Keywords

Cerium oxide nanoparticle; Nanoparticles; Neurodegeneration; Neurotrophins; Targeted therapy

Abstract

Oxidative stress has been found to be associated with the progression of neurodegenerative diseases such as Alzheimers, Parkinsons, Lou Gehrigs, etc. In the recent years, cerium oxide nanoparticles (CNPs) have been studied as potent antioxidant agents able to exert neuroprotective effects. This work reports polyethylene glycol (PEG)-coated and antibody-conjugated CNPs for the selective delivering to Aβ aggregates, and the protective effect against oxidative stress/Aβ-mediated neurodegeneration. In this study PEG-coated and anti-Aβ antibody-conjugated antioxidant nanoparticles (Aβ-CNPs-PEG) were developed, and their effects on neuronal survival and brain-derived neurotrophic factor (BDNF) signaling pathway were examined. Aβ-CNPs-PEG specifically targets the Aβ aggregates, and concomitant rescue of neuronal survival better than Aβ-CNPs, by modulating the BDNF signaling pathway. This proof of concept work may allow in the future, once validated in vivo, for the selective delivery of CNPs only to affected brain areas. © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Publication Date

1-1-2012

Publication Title

Acta Biomaterialia

Volume

8

Issue

6

Number of Pages

2056-2067

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.actbio.2012.01.035

Socpus ID

84863417805 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84863417805

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