Title
Stem Cells In The Diabetic Infarcted Heart
Keywords
Diabetes; Embryonic stem cells; Hyperglycemia; Myocardial infarction; Oxidative stress
Abstract
Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant advances in pharmacological interventions and surgical techniques, the disease progression leading to diabetic end-stage heart failure remains very high. Recently, cell therapy has gained much attention as an alternative approach to treat various heart diseases. However, transplanted stem cell studies in diabetic animal models are very limited. In this review, we discuss the pathogenesis of the diabetic infarcted heart and the potential of stem cell therapy to repair and regenerate. © 2010 Springer Science+Business Media, LLC.
Publication Date
11-1-2010
Publication Title
Heart Failure Reviews
Volume
15
Issue
6
Number of Pages
581-588
Document Type
Review
Personal Identifier
scopus
DOI Link
https://doi.org/10.1007/s10741-010-9172-8
Copyright Status
Unknown
Socpus ID
78149357221 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/78149357221
STARS Citation
Glass, Carley E.; Singal, Pawan K.; and Singla, Dinender K., "Stem Cells In The Diabetic Infarcted Heart" (2010). Scopus Export 2010-2014. 600.
https://stars.library.ucf.edu/scopus2010/600