Title

Stem Cells In The Diabetic Infarcted Heart

Keywords

Diabetes; Embryonic stem cells; Hyperglycemia; Myocardial infarction; Oxidative stress

Abstract

Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant advances in pharmacological interventions and surgical techniques, the disease progression leading to diabetic end-stage heart failure remains very high. Recently, cell therapy has gained much attention as an alternative approach to treat various heart diseases. However, transplanted stem cell studies in diabetic animal models are very limited. In this review, we discuss the pathogenesis of the diabetic infarcted heart and the potential of stem cell therapy to repair and regenerate. © 2010 Springer Science+Business Media, LLC.

Publication Date

11-1-2010

Publication Title

Heart Failure Reviews

Volume

15

Issue

6

Number of Pages

581-588

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/s10741-010-9172-8

Socpus ID

78149357221 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/78149357221

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