Title

Non-Phosgene Route To Unsymmetrical Ureas From N-Cbz-Α-Amino Acid Amides

Keywords

α-Amino acid amides; Non-phosgene; Rearrangement; Urea synthesis

Abstract

A convenient method toward the synthesis of α-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-α-amino acids 1, which presumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity. © 2013 Elsevier Ltd. All rights reserved.

Publication Date

10-2-2013

Publication Title

Tetrahedron Letters

Volume

54

Issue

40

Number of Pages

5467-5469

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.tetlet.2013.07.141

Socpus ID

84883453537 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84883453537

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