Title
Non-Phosgene Route To Unsymmetrical Ureas From N-Cbz-Α-Amino Acid Amides
Keywords
α-Amino acid amides; Non-phosgene; Rearrangement; Urea synthesis
Abstract
A convenient method toward the synthesis of α-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-α-amino acids 1, which presumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity. © 2013 Elsevier Ltd. All rights reserved.
Publication Date
10-2-2013
Publication Title
Tetrahedron Letters
Volume
54
Issue
40
Number of Pages
5467-5469
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1016/j.tetlet.2013.07.141
Copyright Status
Unknown
Socpus ID
84883453537 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84883453537
STARS Citation
Ghazvini Zadeh, Ebrahim H.; Abo-Dya, Nader E.; Sotuyo, Ania C.; Ghiviriga, Ion; and Hall, C. Dennis, "Non-Phosgene Route To Unsymmetrical Ureas From N-Cbz-Α-Amino Acid Amides" (2013). Scopus Export 2010-2014. 6319.
https://stars.library.ucf.edu/scopus2010/6319