Title
Β-Hydroxy-Β-Methylbutyrate (Hmb)-Free Acid Attenuates Circulating Tnf-Α And Tnfr1 Expression Postresistance Exercise
Abstract
The purpose of this study was to examine the effect of β-hydroxy- β-methylbutyrate-free acid (HMB-FA) and cold-water immersion (CWI) on circulating concentrations of TNF-α and monocyte TNF-α receptor 1 (TNFR1) expression. Forty resistance-trained men (22.3 ± 2.4 yr) were randomized into four groups [placebo (PL), HMB-FA, CWI, and HMB-FA-CWI] and performed an acute, intense exercise protocol (four sets of up to 10 repetitions of the squat, dead lift, and split squat). Participants also performed four sets of up to 10 repetitions of the squat at 24 and 48 h following the initial exercise bout. Blood was sampled before exercise (PRE), immediately postexercise (IP), and 30 min, 24 h, and 48 h postexercise (30P, 24P, and 48P, respectively). Circulating TNF-α was assayed, and TNFR1 expression on CD14+ monocytes was measured by flow cytometry. The exercise protocol significantly elevated TNF-α in only PL (P = 0.006) and CWI (P = 0.045) IP. Mean percent changes show that TNF-α significantly increased from PRE to IP for only PL and CWI groups (P < 0.05), whereas the percent change of TNF-α for HMB-FA and HMB-FA-CWI was not significant. TNFR1 expression was elevated in PL (P = 0.023) and CWI (P = 0.02) at 30P compared with PRE, whereas both HMB-FA-treated groups did not increase significantly. In conclusion, HMB-FA attenuated circulating TNF-α IP and TNFR1 expression during recovery compared with PL and CWI. HMB-FA supplementation may attenuate the initial immune response to intense exercise, which may reduce recovery time following intense exercise. Copyright © 2013 the American Physiological Society.
Publication Date
10-15-2013
Publication Title
Journal of Applied Physiology
Volume
115
Issue
8
Number of Pages
1173-1182
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1152/japplphysiol.00738.2013
Copyright Status
Unknown
Socpus ID
84886032355 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84886032355
STARS Citation
Townsend, Jeremy R.; Fragala, Maren S.; Jajtner, Adam R.; Gonzalez, Adam M.; and Wells, Adam J., "Β-Hydroxy-Β-Methylbutyrate (Hmb)-Free Acid Attenuates Circulating Tnf-Α And Tnfr1 Expression Postresistance Exercise" (2013). Scopus Export 2010-2014. 6346.
https://stars.library.ucf.edu/scopus2010/6346