Title

Interplay Between Velocity And Travel Distance Of Kinesin-Based Transport In The Presence Of Tau

Abstract

Although the disease-relevant microtubule-associated protein tau is known to severely inhibit kinesin-based transport in vitro, the potential mechanisms for reversing this detrimental effect to maintain healthy transport in cells remain unknown. Here we report the unambiguous upregulation of multiple-kinesin travel distance despite the presence of tau, via decreased single-kinesin velocity. Interestingly, the presence of tau also modestly reduced cargo velocity in multiple-kinesin transport, and our stochastic simulations indicate that the tau-mediated reduction in single-kinesin travel underlies this observation. Taken together, our observations highlight a nontrivial interplay between velocity and travel distance for kinesin transport, and suggest that single-kinesin velocity is a promising experimental handle for tuning the effect of tau on multiple-kinesin travel distance. © 2013 Biophysical Society.

Publication Date

11-19-2013

Publication Title

Biophysical Journal

Volume

105

Issue

10

Number of Pages

-

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.bpj.2013.10.006

Socpus ID

84887974307 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84887974307

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