Title

Antiviral Activity Of Retrocyclin Rc-101, A Candidate Microbicide Against Cell-Associated Hiv-1

Abstract

Microbicides have been evaluated mostly against cell-free HIV-1. Because semen contains both cell-free and cell-associated HIV-1, HIV-1 transmission could occur via either or both sources. Therefore, it is important to examine the antiviral activity of microbicides against cell-associated HIV-1. The cyclic antimicrobial peptide retrocyclin RC-101 has been shown previously to have antiviral activity against cell-free HIV-1, with no associated cellular toxicity. In this article we have examined the antiviral activity of RC-101 against cell-associated HIV-1. The results demonstrate potent antiviral activity of RC-101 against cell-cell HIV-1 transmission in both CD4-dependent and CD4-independent assays against CCR5- and CXCR4-tropic HIV-1, with no cellular toxicity. Furthermore, this antiviral activity was retained in the presence of human seminal plasma. The potent antiviral activity of RC-101 against cell-associated HIV-1 reported here, and the previously reported antiviral activity in cervical tissues, suggest that RC-101 is an excellent and promising microbicide candidate against HIV-1. © 2013 Mary Ann Liebert, Inc.

Publication Date

2-1-2013

Publication Title

AIDS Research and Human Retroviruses

Volume

29

Issue

2

Number of Pages

391-396

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1089/aid.2012.0135

Socpus ID

84872965125 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84872965125

This document is currently not available here.

Share

COinS