Title

Selective Cell Death By Photochemically Induced Ph Imbalance In Cancer Cells

Abstract

Singlet oxygen sensitized photodynamic therapy (PDT) relies on the concentration of oxygen in the tissue to be treated. Most cancer lesions, however, have poor vasculature and, as a result, are hypoxic, significantly hindering PDT efficacies. An oxygen-independent PDT method may circumvent this limitation. To address this, we prepared sulfonium salts that produced a pH drop within HCT 116 cells via the generation of a photoacid within the cytosol. This process was driven by one- or two-photon absorption (1PA or 2PA) of the endocytosed photoacid generators (PAGs). One of these PAGs, which had a significantly lower dark cytotoxicity and was more efficient in generating a photoacid, effectively induced necrotic cell death in the HCT 116 cells. The data suggest that PAGs may be an attractive alternative PDT modality to selectively induce cell death in oxygen-deprived tissue such as tumors. © 2013 American Chemical Society.

Publication Date

2-13-2013

Publication Title

Journal of the American Chemical Society

Volume

135

Issue

6

Number of Pages

2112-2115

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/ja3122312

Socpus ID

84873696352 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84873696352

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