Title

Effects Of Cerium Oxide Nanoparticles On The Growth Of Keratinocytes, Fibroblasts And Vascular Endothelial Cells In Cutaneous Wound Healing

Keywords

Cerium oxide nanoparticles; Fibroblasts; Keratinocytes; Oxidative stress; Vascular endothelial cells; Wound healing

Abstract

Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles. © 2012 .

Publication Date

3-1-2013

Publication Title

Biomaterials

Volume

34

Issue

9

Number of Pages

2194-2201

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.biomaterials.2012.11.061

Socpus ID

84872383569 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84872383569

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