Title

A Moment-Based Approach For Dvh-Guided Radiotherapy Treatment Plan Optimization

Abstract

The dose-volume histogram (DVH) is a clinically relevant criterion to evaluate the quality of a treatment plan. It is hence desirable to incorporate DVH constraints into treatment plan optimization for intensity modulated radiation therapy. Yet, the direct inclusion of the DVH constraints into a treatment plan optimization model typically leads to great computational difficulties due to the non-convex nature of these constraints. To overcome this critical limitation, we propose a new convex-moment-based optimization approach. Our main idea is to replace the non-convex DVH constraints by a set of convex moment constraints. In turn, the proposed approach is able to generate a Pareto-optimal plan whose DVHs are close to, or if possible even outperform, the desired DVHs. In particular, our experiment on a prostate cancer patient case demonstrates the effectiveness of this approach by employing two and three moment formulations to approximate the desired DVHs. © 2013 Institute of Physics and Engineering in Medicine.

Publication Date

3-21-2013

Publication Title

Physics in Medicine and Biology

Volume

58

Issue

6

Number of Pages

1869-1887

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1088/0031-9155/58/6/1869

Socpus ID

84874865982 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84874865982

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