Title
Preeradication Vaccine Policy Options For Poliovirus Infection And Disease Control
Keywords
Policy options; Poliovirus; Vaccination
Abstract
With the circulation of wild poliovirus (WPV) types 1 and 3 continuing more than a decade after the original goal of eradicating all three types of WPVs by 2000, policymakers consider many immunization options as they strive to stop transmission in the remaining endemic and outbreak areas and prevent reintroductions of live polioviruses into nonendemic areas. While polio vaccination choices may appear simple, our analysis of current options shows remarkable complexity. We offer important context for current and future polio vaccine decisions and policy analyses by developing decision trees that clearly identify potential options currently used by countries as they evaluate national polio vaccine choices. Based on a comprehensive review of the literature we (1) identify the current vaccination options that national health leaders consider for polio vaccination, (2) characterize current practices and factors that appear to influence national and international choices, and (3) assess the evidence of vaccine effectiveness considering sources of variability between countries and uncertainties associated with limitations of the data. With low numbers of cases occurring globally, the management of polio risks might seem like a relatively low priority, but stopping live poliovirus circulation requires making proactive and intentional choices to manage population immunity in the remaining endemic areas and to prevent reestablishment in nonendemic areas. Our analysis shows remarkable variability in the current national polio vaccine product choices and schedules, with combination vaccine options containing inactivated poliovirus vaccine and different formulations of oral poliovirus vaccine making choices increasingly difficult for national health leaders. © 2013 Society for Risk Analysis.
Publication Date
4-1-2013
Publication Title
Risk Analysis
Volume
33
Issue
4
Number of Pages
516-543
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1111/risa.12019
Copyright Status
Unknown
Socpus ID
84875928962 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/84875928962
STARS Citation
Thompson, Kimberly M.; Pallansch, Mark A.; Duintjer Tebbens, Radboud J.; Wassilak, Steve G.; and Kim, Jong Hoon, "Preeradication Vaccine Policy Options For Poliovirus Infection And Disease Control" (2013). Scopus Export 2010-2014. 6834.
https://stars.library.ucf.edu/scopus2010/6834