Title

Microfabricated Mammalian Organ Systems And Their Integration Into Models Of Whole Animals And Humans

Abstract

While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ 'body-on-a-chip' systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry. © 2013 The Royal Society of Chemistry.

Publication Date

4-7-2013

Publication Title

Lab on a Chip

Volume

13

Issue

7

Number of Pages

1201-1212

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1039/c3lc41017j

Socpus ID

84874894377 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84874894377

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