Title

Buffer-Stable Chitosan-Polyglutamic Acid Hybrid Nanoparticles For Biomedical Applications

Keywords

Biodegradation; Biohybrid materials; Buffer-stable; Chitosan; Polyelectrolytes

Abstract

In spite of their attractive features, widespread biomedical applications of CS nanoparticles are yet to be realized due to their poor stability in physiological conditions, such as in buffer system at pH 7.4. Buffer-stable chitosan-based hybrid NPs (HNPs) are reported and characterized. Buffer stability is achieved by introducing polyglutamic acid to chitosan. The effect of PGA to CS molar ratio and crosslinking on HNP integrity, buffer stability, and biodegradability are studied. Preliminary in vitro studies are carried out to evaluate targeted uptake efficiency of folate conjugated HNPs. Successful demonstration of buffer stability and cancer cell targeting by HNPs achieves important milestones for chitosan-based nanoparticle technology. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Publication Date

5-1-2013

Publication Title

Macromolecular Bioscience

Volume

13

Issue

5

Number of Pages

603-613

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1002/mabi.201200425

Socpus ID

84878137835 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84878137835

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