Title

Decreased Levels Of Proapoptotic Factors And Increased Key Regulators Of Mitochondrial Biogenesis Constitute New Potential Beneficial Features Of Long-Lived Growth Hormone Receptor Gene-Disrupted Mice

Keywords

Aging; Apoptosis; Calorie restriction; Dwarf mice; GHRKO mice; Longevity; Mitochondrial biogenesis; Visceral fat removal

Abstract

Decreased somatotrophic signaling is among the most important mechanisms associated with extended longevity. Mice homozygous for the targeted disruption of the growth hormone (GH) receptor gene (GH receptor knockout; GHRKO) are obese and dwarf, are characterized by a reduced weight and body size, undetectable levels of GH receptor, high concentration of serum GH, and greatly reduced plasma levels of insulin and insulin-like growth factor-I, and are remarkably long lived. Recent results suggest new features of GHRKO mice that may positively affect longevity - decreased levels of proapoptotic factors and increased levels of key regulators of mitochondrial biogenesis. The alterations in levels of the proapoptotic factors and key regulators of mitochondrial biogenesis were not further improved by two other potential life-extending interventions - calorie restriction and visceral fat removal. This may attribute the primary role to GH resistance in the regulation of apoptosis and mitochondrial biogenesis in GHRKO mice in terms of increased life span. © 2012 © The Author 2012. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.

Publication Date

6-1-2013

Publication Title

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volume

68

Issue

6

Number of Pages

639-651

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1093/gerona/gls231

Socpus ID

84878292533 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84878292533

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