Title

Liquid Crystal Based Biosensors For Bile Acid Detection

Keywords

and liquid crystal films; bile acid; detection; surfactants

Abstract

The concentration level of bile acids is a useful indicator for early diagnosis of liver diseases. The prevalent measurement method in detecting bile acids is the chromatography coupled with mass spectrometry, which is precise yet expensive. Here we present a biosensor platform based on liquid crystal (LC) films for the detection of cholic acid (CA). This platform has the advantage of low cost, label-free, solution phase detection and simple analysis. In this platform, LC film of 4-Cyano-4'-pentylbiphenyl (5CB) was hosted by a copper grid supported with a polyimide-coated glass substrate. By immersing into sodium dodecyl sulfate (SDS) solution, the LC film was coated with SDS which induced a homeotropic anchoring of 5CB. Addition of CA introduced competitive adsorption between CA and SDS at the interface, triggering a transition from homeotropic to homogeneous anchoring. The detection limit can be tuned by changing the pH value of the solution from 12uM to 170uM. © 2013 SPIE.

Publication Date

6-7-2013

Publication Title

Proceedings of SPIE - The International Society for Optical Engineering

Volume

8642

Number of Pages

-

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1117/12.2004170

Socpus ID

84878477217 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84878477217

This document is currently not available here.

Share

COinS