Title
Atherosclerosis: Oxidation Hypothesis
Keywords
Animal models; Atherosclerosis; Lipid peroxidation-derived aldehydes; Oxidation hypothesis
Abstract
This chapter points out that lipid peroxidation-derived aldehydes are readily oxidized to carboxylic acids, and many enzyme systems that are suggested to be involved in the oxidation of lipids themselves are capable of accelerating this conversion. There are innumerable animal models of atherosclerosis. Short-term animal models of atherosclerosis have performed well to establish and test the oxidation hypothesis. The models provided evidence of lipid peroxidation and aldehyde accumulation, evidence for the presence of aldehyde-protein adducts, evidence for the presence of core-aldehydes and, above all, evidence for the attenuation of atherosclerosis by a number of antioxidants.
Publication Date
1-1-2013
Publication Title
Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis
Number of Pages
329-344
Document Type
Article; Book Chapter
Personal Identifier
scopus
DOI Link
https://doi.org/10.1002/9781118355886.ch12
Copyright Status
Unknown
Socpus ID
85069986585 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/85069986585
STARS Citation
Narasimhulu, Chandrakala Aluganti; Litvinov, Dmitry; Jiang, Xueting; Yang, Zhaohui; and Parthasarathy, Sampath, "Atherosclerosis: Oxidation Hypothesis" (2013). Scopus Export 2010-2014. 7345.
https://stars.library.ucf.edu/scopus2010/7345