Title

Chipmodule: Systematic Discovery Of Transcription Factors And Their Cofactors From Chip-Seq Data

Abstract

We have developed a novel approach called ChIPModule to systematically discover transcription factors and their cofactors from ChIP-seq data. Given a ChIP-seq dataset and the binding patterns of a large number of transcription factors, ChIPModule can efficiently identify groups of transcription factors, whose binding sites significantly co-occur in the ChIP-seq peak regions. By testing ChIPModule on simulated data and experimental data, we have shown that ChIPModule identifies known cofactors of transcription factors, and predicts new cofactors that are supported by literature. ChIPModule provides a useful tool for studying gene transcriptional regulation.

Publication Date

1-1-2013

Publication Title

Pacific Symposium on Biocomputing

Number of Pages

320-331

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

Socpus ID

84891390878 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84891390878

This document is currently not available here.

Share

COinS