Title

Organic Electrochemical Transistor Based Immunosensor For Prostate Specific Antigen (Psa) Detection Using Gold Nanoparticles For Signal Amplification

Keywords

Conducting polymer; Gold nanoparticle; Immunosensor; Organic electronics; Prostate cancer

Abstract

We demonstrated a highly sensitive organic electrochemical transistor (OECT) based immunosensor with a low detection limit for prostate specific antigen/α1-antichymotrypsin (PSA-ACT) complex. The poly(styrenesulfonate) doped poly(3,4-ethylenedioxythiophene) (PEDOT:PSS) based OECT with secondary antibody conjugated gold nanoparticles (AuNPs) provided a detection limit of the PSA-ACT complex as low as 1. pg/ml, as well as improved sensitivity and a dynamic range, due to the role of AuNPs in the signal amplification. The sensor performances were particularly improved in the lower concentration range where the detection is clinically important for the preoperative diagnosis and screening of prostate cancer. This result shows that the OECT-based immunosensor can be used as a transducer platform acceptable to the point-of-care (POC) diagnostic systems and demonstrates adaptability of organic electronics to clinical applications. © 2010 Elsevier B.V.

Publication Date

7-1-2010

Publication Title

Biosensors and Bioelectronics

Volume

25

Issue

11

Number of Pages

2477-2482

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.bios.2010.04.013

Socpus ID

77953361840 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/77953361840

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