Title

Protein Complexes/Aggregates As Potential Cancer Biomarkers Revealed By A Nanoparticle Aggregation Immunoassay

Keywords

Cancer biomarker; Dynamic light scattering; Gold nanoparticle; Immunoassay; Protein complex/aggregate

Abstract

Protein-protein interactions and protein complex/aggregate formation play an essential role in almost all biological functions and activities. Through a nanoparticle aggregation immunoassay, we discovered that some proteins are substantially more complexed/aggregated in cancer tissues than normal tissues. This study examined four biomarkers proteins, CA125, CEA (carcinoembryonic antigen), CA19-9 and PAP (prostatic acid phosphatase) in ovarian, colon and prostate tissue lysates. The most exciting results were observed from the PAP assay of prostate tissues: prostate cancer can be clearly distinguished from normal prostate and prostate with benign conditions such as BPH (benign prostate hyperplasia) based on the complex/aggregation level of PAP in prostate tissue lysates. The complex/aggregate level of a protein can be potential biomarkers for cancer detection and diagnosis. © 2010 Elsevier B.V.

Publication Date

7-1-2010

Publication Title

Colloids and Surfaces B: Biointerfaces

Volume

78

Issue

2

Number of Pages

259-265

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.colsurfb.2010.03.012

Socpus ID

77952543134 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/77952543134

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