Title

Optical Detection Of Lithocholic Acid With Liquid Crystal Emulsions

Abstract

The concentration level of bile acids is a clinical biomarker for the diagnosis of intestinal diseases because individuals suffering from intestinal diseases have a sharply increased concentration of bile acids at micromolar levels. Here, we report the detection of lithocholic acid (LCA) in aqueous solution by using surfactant-stabilized 4-n-pentyl-4′-cyanobiphenyl (5CB) liquid crystal droplets as an optical probe. We find that the surfactant adsorbed at the 5CB/water interface can be replaced by LCA, triggering a radial-to-bipolar configuration transition of the 5CB in the droplets. By simply observing the LCA-triggered transition with a polarizing optical microscope, micromolar levels of LCA in aqueous solution can be detected. The detection limit and selectivity of surfactant-stabilized 5CB droplets for LCA depend on the chain length and headgroup of the surfactants used for stabilizing 5CB droplets. © 2012 American Chemical Society.

Publication Date

1-8-2013

Publication Title

Langmuir

Volume

29

Issue

1

Number of Pages

387-392

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1021/la303771t

Socpus ID

84872103372 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84872103372

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