Title

Update On Clinical Trials For The Prevention Of Acute Kidney Injury In Patients Undergoing Cardiac Surgery

Keywords

Acute kidney injury; Cardiac surgery; Clinical trials; Diagnosis; Prevention; Treatment

Abstract

Background: Effective therapeutic agents for the prevention and treatment of acute kidney injury (AKI) after cardiac surgery remain elusive despite the tremendous advances in surgical techniques, technology, and understanding of disease processes. Recent developments and their effect on the incidence of AKI after cardiac surgery are discussed. Data Sources: Published clinical trials in PubMed, strength of evidence assessed by the guidelines of the American Family Physicians. Conclusions: The definition of AKI has changed, and the focus of interventions has shifted from treatment to prevention to recovery from AKI. Antioxidants and biological agents have been added to classic armaments of hydration and diuretics in addition to tighter metabolic control to prevent AKI. Although the treatment options remain unsatisfactory, a lot of progress nevertheless continues to be made in the prevention and treatment of AKI. © 2013 Elsevier Inc.

Publication Date

1-1-2013

Publication Title

American Journal of Surgery

Volume

206

Issue

1

Number of Pages

86-95

Document Type

Review

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.amjsurg.2012.08.007

Socpus ID

84879201182 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84879201182

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