Title
Novel Hydrophilic Bis(1,2,3-Triazolyl)Fluorenyl Probe For In Vitro Zinc Ion Sensing
Keywords
1,2,3-triazolyl-fluorene; binding constant; fluorescent probe; metal sensing; two-photon microscopy bioimaging; zinc ion sensing
Abstract
A hydrophilic bis(1,2,3-triazolyl)fluorene derivative was synthesized as a multi-photon-absorbing, zinc-ion-sensing fluorescent probe. The fluorescence response was approximately five-fold greater in presence of Zn2+, resulting in a large binding constant (1 × 109) for a 1:2 ligand to zinc complex. A four-fold increase in the two-photon absorption cross section was achieved upon binding Zn2+. In vitro two-photon fluorescence microscopy imaging revealed a significant fluorescence increase upon introduction of Zn2+ into HeLa cells and reversible Zn 2+ binding, demonstrating the potential of this probe for zinc ion sensing. © 2010 American Chemical Society.
Publication Date
11-24-2010
Publication Title
ACS Applied Materials and Interfaces
Volume
2
Issue
11
Number of Pages
2978-2981
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1021/am100719v
Copyright Status
Unknown
Socpus ID
79151481873 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/79151481873
STARS Citation
Nguyen, Dao M.; Wang, Xuhua; Ahn, Hyo Yang; Rodriguez, Luis; and Bondar, Mikhailo V., "Novel Hydrophilic Bis(1,2,3-Triazolyl)Fluorenyl Probe For In Vitro Zinc Ion Sensing" (2010). Scopus Export 2010-2014. 80.
https://stars.library.ucf.edu/scopus2010/80