Title

Mcp-Induced Protein 1 Suppresses Tnfα-Induced Vcam-1 Expression In Human Endothelial Cells

Keywords

Adhesion molecule; Endothelial cell; Inflammation; MCPIP1; NF-κB signaling

Abstract

Endothelial inflammation plays a critical role in the development and progression of cardiovascular disease, albeit the mechanisms need to be fully elucidated. We here report that treatment of human umbilical vein endothelial cells (HUVECs) with tumor necrosis factor (TNF) α substantially increased the expression of MCP-induced protein 1 (MCPIP1). Overexpression of MCPIP1 protected ECs against TNFα-induced endothelial activation, as characterized by the attenuation in the expression of the adhesion molecule VCAM-1 and monocyte adherence to ECs. Conversely, small interfering RNA-mediated knock down of MCPIP1 increased the expression of VCAM-1 and monocytic adherence to ECs. These studies identified MCPIP1 as a feedback control of cytokines-induced endothelial inflammation. © 2010 Federation of European Biochemical Societies.

Publication Date

7-1-2010

Publication Title

FEBS Letters

Volume

584

Issue

14

Number of Pages

3065-3072

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.febslet.2010.05.040

Socpus ID

77954176472 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/77954176472

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