Title

Hyperleptinemia Is Associated With Crp But Not Apolipoprotein E And Is Reduced By Exercise Training

Keywords

Endurance training; Exercise physiology; Gender; Metabolism

Abstract

The purpose of this study was to examine whether leptin levels affect the response of leptin to exercise training (ET) and whether this is also affected by C-reactive protein (CRP) or the three common Apolipoprotein E genotypes (APOE). Ninety-seven (male = 45, female = 52) sedentary individuals underwent 6 months of supervised ET. Blood was sampled before the initiation of ET, and again 24 and 72 hr after completion of the final training session. ET resulted in a small reduction in body mass (80.47 ± 18.03 vs 79.42 ± 17.34 kg, p < .01). Leptin was reduced 24 hr after the final exercise session (p < .01), but returned to normal after 72 hr (p > .05)-Pre: 13.51 ± 12.27, 24hr: 12.14 ± 12.34, 72hr: 12.98 ± 11.40 ng/ml. The most hyperleptinemic individuals had a greater initial response, which was sustained through to 72 hr after the final session in the pooled study population (p < .01), and in both males (p < .05) and females (p < .05) separately. CRP was related to leptin independently of body weight and positively related to the reductions in leptin. APOE genotype was not related to leptin levels and did not affect the response to ET. Leptin levels may only be reduced by ET in those with hyperleptinemia. In addition, both the initial extent of hyperleptinemia and the subsequent reduction in leptin may be related to low grade chronic systemic inflammation.

Publication Date

10-1-2014

Publication Title

International Journal of Sport Nutrition and Exercise Metabolism

Volume

24

Issue

5

Number of Pages

524-531

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1123/ijsnem.2013-0200

Socpus ID

84908213377 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84908213377

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