Title

Proteome-Genome Complexity As A Metric Of Refractory Disease

Keywords

Boolean networks; Complexity; Genomics; Network medicine; Proteomics; Refractory disease

Abstract

Treatment decisions for refractory diseases are frequently challenging because the benefits of disease-free survival and relief of symptoms must be balanced against the severity and frequency of side effects. A precise measure of disease resistance would therefore be valuable when assessing possible treatment strategies. In recent years there has been much interest in the modeling of proteomes and genomes as a means of identifying major pathways of disease causation. We suggest that these analyses may offer the additional benefit of quantifying refractory.

Publication Date

10-4-2014

Publication Title

Journal of Proteomics

Volume

110

Number of Pages

195-197

Document Type

Letter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.jprot.2014.08.005

Socpus ID

84908275701 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84908275701

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