Title

Immunosuppressive Drugs And Fetal Outcome

Keywords

fetus; immunosuppression; pregnancy; transplantation

Abstract

Successful pregnancies have been reported in all types of solid-organ transplant recipients on a variety of immunosuppressive regimens. Immunosuppression is essential to maintain the transplanted organ and maternal health, thus the safety of these medications continues to be studied. This article reviews information in the literature and data from the National Transplantation Pregnancy Registry (NTPR) in the United States related to immunosuppressive medication and pregnancy. Although most maintenance immunosuppressive regimens have not been shown to affect the outcome of posttransplant pregnancies, mycophenolic acid products are associated with an increased incidence of spontaneous abortion and an increase in the incidence and a specific pattern of birth defects. When counseling transplant recipients about the prospect and safety of pregnancy, the health of the mother, her graft, and the developing fetus must all be taken into account.

Publication Date

11-1-2014

Publication Title

Best Practice and Research: Clinical Obstetrics and Gynaecology

Volume

28

Issue

8

Number of Pages

1174-1187

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.bpobgyn.2014.07.020

Socpus ID

84927166570 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84927166570

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