Title

Mcp-1And Il-1Β Expression In The Myocardia Of Two Young Patients With Type 1 Diabetes Mellitus And Fatal Diabetic Ketoacidosis

Keywords

Diabetic cardiomyopathy; Diabetic ketoacidosis; IL-1β; MCP-1; Obesity; Type 1 diabetes mellitus

Abstract

Convincing evidence exists for the early onset of diabetic cardiomyopathy and coronary artery disease (CAD) as distinct forms of cardiac disease in young patients with Type 1 diabetes mellitus (T1DM) and the pre-stages of T2DM, forms of dysregulated insulin signaling. Progression of both chronic cardiac conditions is mediated by oxidative stress and low grade inflammation. This study reports the expression of monocyte chemotactic protein-1 (MCP-1) chemokine and the interleukin (IL)-1β inflammatory cytokine in two young patients with suboptimal metabolic control and fatal diabetic ketoacidosis (DKA), two age-matched overweight/obesity cases and two age-matched controls. In addition, markers of oxidative stress, apoptosis, collagen deposition and cardiomyocyte hypertrophy were studied. Significant expression of MCP-1 and IL-1β was seen in the myocardia of the T1DM/DKA cases, with lesser amounts expressed in the overweight/obesity myocardia. All of the other markers except cardiomyocyte hypertrophy were expressed to a significantly greater extent in the T1DM/DKA and overweight/obesity cases in comparison to the age-matched controls. Cardiomyocyte hypertrophy was significantly greater in the overweight/obesity cases than in the T1DM/DKA or the control cases. © 2013 Elsevier Inc.

Publication Date

2-1-2014

Publication Title

Experimental and Molecular Pathology

Volume

96

Issue

1

Number of Pages

71-79

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.yexmp.2013.11.001

Socpus ID

84891753120 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84891753120

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