Title

Characterization Of Liposomes And Silica Nanoparticles Using Resistive Pulse Method

Keywords

Electrophoresis; Liposomes; Nanoparticles; Nanopipette; Nanopores; Translocations

Abstract

The ability to precisely count inorganic and organic nanoparticles and to measure their size distribution plays a major role in various applications such as drug delivery, nanoparticles counting, and many others. Here we employ a simple resistive pulse method that allows translocations, counting, and measuring size and velocity distribution of silica nanoparticles and liposomes with diameters from 50. nm to 250. nm. This technique is based on the Coulter counter technique but has nanometer size pores. It was found that ionic current drops when nanoparticles enter the nanopore of a pulled micropipette, producing a clear translocation signal. Pulled borosilicate micropipettes with opening 50-350. nm were used as the detecting instrument. This method provides a direct, fast and cost-effective way to characterize inorganic and organic nanoparticles in a solution. © 2014 Elsevier B.V.

Publication Date

4-20-2014

Publication Title

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Volume

448

Issue

1

Number of Pages

9-15

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.colsurfa.2014.01.080

Socpus ID

84896897629 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84896897629

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