Title
Preservation On Calcium Homeostasis Is Involved In Mitochondrial Protection Of Limonium Sinense Against Liver Damage In Mice
Keywords
D-galactosamine; Limonium sinense (Girard) Ktze; lipopolysaccharide; mitochondrial Ca overload 2+; mitochondrial Ca -ATPase activity 2+
Abstract
Mechanisms underlying the mitochondrial protection of Limonium sinense extracts (LSE) was studied in lipopolysaccharide and D-galactosamine (LPS/D-GalN) intoxicated mice. It was found that increased activities of serum aspartate aminotransferase and alanine aminotransferase induced by LPS/D-GalN were significantly inhibited by pretreatment with LSE. The obvious disruption of membrane potential, intramitochondrial Ca 2+ overload and suppression in mitochondrial Ca 2+-ATPase activity induced by LPS/D-GalN were significantly blocked by pretreatment with LSE. It was concluded that mechanisms underlying protection of LSE against liver mitochondria damage might be related to the preservation on mitochondrial Ca 2+ homeostasis through the preservation on mitochondrial Ca 2+-ATPase activity.
Publication Date
7-1-2010
Publication Title
Pharmacognosy Magazine
Volume
6
Issue
23
Number of Pages
191-197
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.4103/0973-1296.66935
Copyright Status
Unknown
Socpus ID
78049385324 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/78049385324
STARS Citation
Tang, Xin Hui; Chen, Jin; Yang, Xiao Lan; Yan, Li Fang; and Gao, Jing, "Preservation On Calcium Homeostasis Is Involved In Mitochondrial Protection Of Limonium Sinense Against Liver Damage In Mice" (2010). Scopus Export 2010-2014. 887.
https://stars.library.ucf.edu/scopus2010/887