Title

Preservation On Calcium Homeostasis Is Involved In Mitochondrial Protection Of Limonium Sinense Against Liver Damage In Mice

Keywords

D-galactosamine; Limonium sinense (Girard) Ktze; lipopolysaccharide; mitochondrial Ca overload 2+; mitochondrial Ca -ATPase activity 2+

Abstract

Mechanisms underlying the mitochondrial protection of Limonium sinense extracts (LSE) was studied in lipopolysaccharide and D-galactosamine (LPS/D-GalN) intoxicated mice. It was found that increased activities of serum aspartate aminotransferase and alanine aminotransferase induced by LPS/D-GalN were significantly inhibited by pretreatment with LSE. The obvious disruption of membrane potential, intramitochondrial Ca 2+ overload and suppression in mitochondrial Ca 2+-ATPase activity induced by LPS/D-GalN were significantly blocked by pretreatment with LSE. It was concluded that mechanisms underlying protection of LSE against liver mitochondria damage might be related to the preservation on mitochondrial Ca 2+ homeostasis through the preservation on mitochondrial Ca 2+-ATPase activity.

Publication Date

7-1-2010

Publication Title

Pharmacognosy Magazine

Volume

6

Issue

23

Number of Pages

191-197

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.4103/0973-1296.66935

Socpus ID

78049385324 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/78049385324

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