Title

Metabolic Effects Of Abdominal Fats In Animal Models And Humans

Keywords

Abdominal obesity; Adipose tissue; Cancer; Cardiovascular disease; Diabetes; Inflammation; Longevity; Metabolic syndrome; Obesity

Abstract

The prevalence of obesity has reached epidemic levels since the mid-1990s. Obesity is a major health problem in developed countries; it is estimated that approximately 300. million people worldwide are obese. Obesity is characterized by the excessive accumulation of adipose tissue, which predisposes the body to several chronic diseases. However, it is well established that accumulation of abdominal rather than total body fat in obese or nonobese patients is the major contributor to the growing global disease burden. Human and animal studies have shown that excessive accumulation of abdominal adipose tissue causes chronic low-grade inflammation, metabolic syndrome, and type 2 diabetes, and increases the risk of cardiovascular diseases and cancer. There is also strong evidence that abdominal obesity increases mortality and shortens the life span. Preventing obesity and, more importantly, restricting abdominal fat accumulation are the main challenges for scientists and medical practitioners for improving the health span and life span of human populations. © 2014 Elsevier Inc. All rights reserved.

Publication Date

1-1-2014

Publication Title

Nutrition in the Prevention and Treatment of Abdominal Obesity

Number of Pages

295-306

Document Type

Article; Book Chapter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/B978-0-12-407869-7.00027-1

Socpus ID

84902622221 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84902622221

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