Title

Mechanisms For Control Of Biological Electron Transfer Reactions

Keywords

Amicyanin; Coupled electron transfer; Electronic coupling; Gated electron transfer; Hole hopping; MauG; Quinoprotein; Reorganization energy

Abstract

Electron transfer (ET) through and between proteins is a fundamental biological process. The rates and mechanisms of these ET reactions are controlled by the proteins in which the redox centers that donate and accept electrons reside. The protein influences the magnitudes of the ET parameters, the electronic coupling and reorganization energy that are associated with the ET reaction. The protein can regulate the rates of the ET reaction by requiring reaction steps to optimize the system for ET, leading to kinetic mechanisms of gated or coupled ET. Amino acid residues in the segment of the protein through which long range ET occurs can also modulate the ET rate by serving as staging points for hopping mechanisms of ET. Specific examples are presented to illustrate these mechanisms by which proteins control rates of ET reactions.

Publication Date

1-1-2014

Publication Title

Bioorganic Chemistry

Volume

57

Number of Pages

213-221

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/j.bioorg.2014.06.006

Socpus ID

84913549449 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84913549449

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