Title

Nanoceria And Thioredoxin Regulate A Common Antioxidative Gene Network In Tubby Mice

Keywords

Nanoceria; Oxidative stress and antioxidant defense; PCR array; Thioredoxin; Tubby mouse

Abstract

Oxidative stress is a node common to the causes and effects of various ocular diseases. We have shown that thioredoxin has neuroprotective effects on tubby photoreceptors. We also demonstrated that nanoceria (cerium oxide nanoparticles), which are direct antioxidants, have long-term effects on prevention of retinal degeneration in tubby mice. Here, using commercially available PCR array plates, we surveyed the regulation in expression of 89 oxidative stress-associated genes in the eyes of P12 tubby mice which are either intravitreally injected with nanoceria or in which the Trx gene is overexpressed. Our data demonstrate that nanoceria and Trx regulate the same group of genes associated with antioxidative stress and antioxidant defense.

Publication Date

1-1-2014

Publication Title

Advances in Experimental Medicine and Biology

Volume

801

Number of Pages

829-836

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1007/978-1-4614-3209-8_104

Socpus ID

84904818727 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84904818727

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