On-Chip Detection Of Single Vesicle Release From Neuroblastoma Cells Using Monolithic Cmos Bioelectronics

Abstract

Neuroblastoma cells are often used as a cell model to study Parkinson's disease, which causes reduced dopamine release in substantia nigra, the midbrain that controls movements. In this paper, we developed a 1024-ch monolithic CMOS sensor array that has the spatiotemporal resolution as well as low-noise performance to monitor single vesicle release of dopamine from neuroblastoma cells. The CMOS device integrates 1024 on-chip electrodes with an individual size of 15 μm× 15 μm and 1024 transimpedance amplifiers for each electrode, which are each capable of measuring sub-pA current. Thus, this device can be used to study the detailed molecular dynamics of dopamine secretion at single vesicle resolution.

Publication Date

10-26-2018

Publication Title

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volume

2018-July

Number of Pages

5065-5068

Document Type

Article; Proceedings Paper

Personal Identifier

scopus

DOI Link

https://doi.org/10.1109/EMBC.2018.8513219

Socpus ID

85056658071 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85056658071

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