Deciphering The Trna-Dependent Lipid Aminoacylation Systems In Bacteria: Novel Components And Structural Advances

Keywords

antimicrobial resistance; cationic antimicrobial peptides; Lipid aminoacylation; tRNA

Abstract

tRNA-dependent addition of amino acids to lipids on the outer surface of the bacterial membrane results in decreased effectiveness of antimicrobials such as cationic antimicrobial peptides (CAMPs) that target the membrane, and increased virulence of several pathogenic species. After a brief introduction to CAMPs and the various bacterial resistance mechanisms used to counteract these compounds, this review focuses on recent advances in tRNA-dependent pathways for lipid modification in bacteria. Phenotypes associated with amino acid lipid modifications and regulation of their expression will also be discussed.

Publication Date

5-4-2018

Publication Title

RNA Biology

Volume

15

Issue

4-5

Number of Pages

480-491

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1080/15476286.2017.1356980

Socpus ID

85044608422 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85044608422

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