Il-15 Supports The Generation Of Protective Lung-Resident Memory Cd4 T Cells

Abstract

Tissue-resident memory T cells (T RM) provide optimal defense at the sites of infection, but signals regulating their development are unclear, especially for CD4 T cells. Here we identify two distinct pathways that lead to the generation of CD4 T RM in the lungs following influenza infection. The T RM are transcriptionally distinct from conventional memory CD4 T cells and share a gene signature with CD8 T RM. The CD4 T RM are superior cytokine producers compared with conventional memory cells, can protect otherwise naive mice against a lethal influenza challenge, and display functional specialization by inducing enhanced inflammatory responses from dendritic cells compared with conventional memory cells. Finally, we demonstrate than an interleukin (IL)-2-dependent and a novel IL-2-independent but IL-15-dependent pathway support the generation of cohorts of lung T RM.

Publication Date

5-1-2018

Publication Title

Mucosal Immunology

Volume

11

Issue

3

Number of Pages

668-680

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1038/mi.2017.101

Socpus ID

85048000789 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85048000789

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