Il-15 Supports The Generation Of Protective Lung-Resident Memory Cd4 T Cells
Abstract
Tissue-resident memory T cells (T RM) provide optimal defense at the sites of infection, but signals regulating their development are unclear, especially for CD4 T cells. Here we identify two distinct pathways that lead to the generation of CD4 T RM in the lungs following influenza infection. The T RM are transcriptionally distinct from conventional memory CD4 T cells and share a gene signature with CD8 T RM. The CD4 T RM are superior cytokine producers compared with conventional memory cells, can protect otherwise naive mice against a lethal influenza challenge, and display functional specialization by inducing enhanced inflammatory responses from dendritic cells compared with conventional memory cells. Finally, we demonstrate than an interleukin (IL)-2-dependent and a novel IL-2-independent but IL-15-dependent pathway support the generation of cohorts of lung T RM.
Publication Date
5-1-2018
Publication Title
Mucosal Immunology
Volume
11
Issue
3
Number of Pages
668-680
Document Type
Article
Personal Identifier
scopus
DOI Link
https://doi.org/10.1038/mi.2017.101
Copyright Status
Unknown
Socpus ID
85048000789 (Scopus)
Source API URL
https://api.elsevier.com/content/abstract/scopus_id/85048000789
STARS Citation
Strutt, T. M.; Dhume, K.; Finn, C. M.; Hwang, J. H.; and Castonguay, C., "Il-15 Supports The Generation Of Protective Lung-Resident Memory Cd4 T Cells" (2018). Scopus Export 2015-2019. 10221.
https://stars.library.ucf.edu/scopus2015/10221