Ectopic Acth And Crh Co-Secreting Tumor Localized By 68Ga-Dota-Tate Pet/Ct

Keywords

18 F-FDG PET/CT; 68 Ga-DOTA-TATE PET/CT; Cushing syndrome; ectopic ACTH/CRH co-secreting tumors; thymus

Abstract

Diagnosis of ectopic adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) co-secreting tumors causing Cushing syndrome (CS) is challenging because these tumors are rare and their diagnosis is frequently confused with Cushing disease (CD), caused by the effect of CRH on the pituitary. We report a case of a 21-year-old male patient who was referred to our institution with persistent hypercortisolemia and CS after undergoing unnecessary transsphenoidal surgery (TSS). 68Ga-DOTA-TATE PET/CT revealed increased tracer uptake in the thymus, which was histologically proven to be a neuroendocrine tumor (NET) that stained positive for ACTH and CRH. Imaging with 18F-FDG PET/CT was not diagnostic.

Publication Date

7-20-2015

Publication Title

Clinical Nuclear Medicine

Volume

40

Issue

7

Number of Pages

576-578

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1097/RLU.0000000000000806

Socpus ID

84931424884 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/84931424884

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