Title

Association Between Hepatitis B Infection And Pancreatic Cancer: A Population-Based Analysis In The United States

Keywords

hepatitis B virus (HBV); National Inpatient Sample; pancreatic cancer; prevalence

Abstract

Objectives The aim of this study was to assess the role of hepatitis B (HepB) infection in the causation of pancreatic cancer and the predictors of pancreatic cancer and mortality. Methods We identified pancreatic cancer patients 11 to 70 years of age from the 2013-2014 National Inpatient Sample. Pearson χ2 test and Student's t-test were used for categorical and continuous variables, respectively. We assessed the association of HepB and pancreatic cancer and the independent mortality predictors by multivariate analyses. Results Of 69,210 pancreatic cancer patients, 175 patients with a history of HepB and 69,035 patients without a history of HepB were identified. Compared with the pancreatic cancer-non-HepB group, the pancreatic cancer-HepB group consisted more of younger (mean, 60.4 [standard deviation, 7.4] years vs 68.2 [standard deviation, 12.1] years), male, black, and Asian patients with low household income and nonelective admissions. The odds of developing pancreatic cancer among the HepB patients were significantly higher (adjusted odds ratio, 1.24; 95% confidence interval, 1.056-1.449; P = 0.008). Black race, age ≥ 65 years, and male sex demonstrated greater odds of mortality. Conclusions This study concluded up to a 24% increased likelihood of pancreatic cancer among the HepB patients. Blacks showed greater odds of pancreatic cancer and related mortality.

Publication Date

8-1-2018

Publication Title

Pancreas

Volume

47

Issue

7

Number of Pages

849-855

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1097/MPA.0000000000001095

Socpus ID

85050472345 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85050472345

This document is currently not available here.

Share

COinS