Dwarf Mice And Aging

Keywords

aging; Ames dwarf; dwarf; GHR-KO; growth hormone

Abstract

Dwarf mice have been studied for many decades, however, the focus of these studies shifted in 1996 when it was shown by Brown-Borg and her coworkers that Ames dwarf (Prop1df) mice are exceptionally long-lived. Since then, Snell dwarf (Pit1dw) and growth hormone receptor knockout (GHR-KO, a.k.a. Laron dwarf) mice were also shown to be exceptionally long-lived, presumably due to their growth hormone (GH)-deficiency or -resistance, respectively. What is of equal importance in these dwarf mice is their extended health span, that is, these animals have a longer period of life lived free of frailty and age-related diseases. This review article focuses on recent studies conducted in these dwarf mice, which concerned brown and white adipose tissue biology, microRNA (miRNA) profiling, as well as early-life dietary and hormonal interventions. Results of these studies identify novel mechanisms linking reduced GH action with extensions of both life span and health span.

Publication Date

1-1-2018

Publication Title

Progress in Molecular Biology and Translational Science

Volume

155

Number of Pages

69-83

Document Type

Article; Book Chapter

Personal Identifier

scopus

DOI Link

https://doi.org/10.1016/bs.pmbts.2017.12.002

Socpus ID

85040606745 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85040606745

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