Application Of Microphysiological Systems To Enhance Safety Assessment In Drug Discovery

Keywords

drug discovery; microphysiological systems; toxicology

Abstract

Enhancing the early detection of new therapies that are likely to carry a safety liability in the context of the intended patient population would provide a major advance in drug discovery. Microphysiological systems (MPS) technology offers an opportunity to support enhanced preclinical to clinical translation through the generation of higher-quality preclinical physiological data. In this review, we highlight this technological opportunity by focusing on key target organs associated with drug safety and metabolism. By focusing on MPS models that have been developed for these organs, alongside other relevant in vitro models, we review the current state of the art and the challenges that still need to be overcome to ensure application of this technology in enhancing drug discovery.

Publication Date

1-6-2018

Publication Title

Annual Review of Pharmacology and Toxicology

Volume

58

Number of Pages

65-82

Document Type

Article

Personal Identifier

scopus

DOI Link

https://doi.org/10.1146/annurev-pharmtox-010617-052722

Socpus ID

85040620605 (Scopus)

Source API URL

https://api.elsevier.com/content/abstract/scopus_id/85040620605

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